Possibly a variation of Mandeville or a French occupational name.
Mandrell is a rare surname-turned-first name of uncertain etymology. It likely derives from the French locational name Mandeville, meaning 'great town,' or may be related to the word 'mandril,' referring to a spindle or lathe in an occupational context. In the United States, it is most famously associated with the Mandrell sisters of country music fame.
Less common today
Mandrell isn't in the latest US Top 1000. It last peaked at #5,445 in 1997.
Country music superstar and television host
Country singer and multi-instrumentalist
Musician and actress
US births per 5-year period, 1990βpresent (SSA data).