Modern combination of Key and Andre
Keyandre is a modern American invented name. It likely combines the prefix 'Key-' with the classic name 'Andre', which is the French form of Andrew, meaning 'manly' or 'strong'.
Less common today
Keyandre isn't in the latest US Top 1000. It last peaked at #5,403 in 2008.
US births per 5-year period, 1990βpresent (SSA data).