Cheerful and noble; or a blend of Jo and Alissa.
Jolissa is a modern American invention, likely created by blending the prefix 'Jo-' (often associated with the French 'Jolie' meaning pretty or the Hebrew 'Joanna' meaning God is gracious) with the name Alissa or Melissa. It carries the cheerful connotations of its components while offering a unique, contemporary sound.
US births per 5-year period, 1990–present (SSA data).