Hill or high place
A rare variant of the Celtic name Brian, likely derived from the Old Celtic word 'bre' meaning hill. It is often considered a misspelling of Brian in a modern context, but it exists as a distinct surname and occasional given name. In English, it is also the vocabulary word for the organ of thought, though this is rarely the intended etymological source for the name.
Less common today
Brain isn't in the latest US Top 1000. It last peaked at #1,260 in 1991.
Genetically enhanced laboratory mouse bent on world domination Β· Pinky and the Brain
The intelligent third-grade friend of Arthur Read Β· Arthur
A member of the Brotherhood of Evil Β· DC Comics
US births per 5-year period, 1990βpresent (SSA data).