Saintly or holy
A modern elaboration of the Spanish name Santa or a feminine form of Santiago. It combines the Latin root for 'saint' with the popular '-iana' suffix, giving it a melodic and rhythmic quality.
Less common today
Santiana isn't in the latest US Top 1000. It last peaked at #10,312 in 2003.
US births per 5-year period, 1990βpresent (SSA data).