Unknown; possibly a variant of Seamus or a created name.
The exact etymology of Samus is unclear. It is often cited as a variant of the Irish name Seamus, which means 'supplanter,' or as a unique creation for the Metroid video game series. In modern usage, it is almost exclusively associated with the iconic female protagonist Samus Aran.
Less common today
Samus isn't in the latest US Top 1000. It last peaked at #11,356 in 2018.
Intergalactic bounty hunter and protagonist of the Metroid series Β· Metroid
US births per 5-year period, 1990βpresent (SSA data).