Gift of God
Matisyn is a modern creative spelling of Madison. It ultimately derives from the English surname meaning 'son of Maud,' with Maud being a Germanic form of Matilda. In recent decades, it has been reinterpreted as a feminine given name associated with the meaning 'gift of God' due to its phonetic similarity to Matthew.
Less common today
Matisyn isn't in the latest US Top 1000. It last peaked at #9,979 in 2007.
US births per 5-year period, 1990βpresent (SSA data).