Defender of mankind
A modern elaboration of the Greek name Alexia, combined with the suffix -anna. It carries the traditional meaning of protection and defense from its root, Alexander, while adding a melodic, feminine flair.
Less common today
Alexianna isn't in the latest US Top 1000. It last peaked at #6,153 in 2014.
US births per 5-year period, 1990βpresent (SSA data).